Benign prostate hyperplasia (BPH) is one of the most common urological problems in mid-aged to elderly men. Risk factors of BPH include family history, obesity, type 2 diabetes, and high oxidative stress. The main medication classes for BPH management are alpha blockers and 5α-reductase inhibitors. However, these conventional medicines cause adverse effects. Lycogen™, extracted from Rhodobacter sphaeroides WL-APD911, is an anti-oxidant and anti-inflammatory compound. In this study, the effect of Lycogen™ was evaluated in rats with testosterone-induced benign prostate hyperplasia (BPH). Testosterone injections and Lycogen™ administration were carried out for 28 days, and body weights were recorded twice per week. The testosterone injection successfully induced a prostate enlargement. BPH-induced rats treated with different doses of Lycogen™ exhibited a significantly decreased prostate index (PI). Moreover, the Lycogen™ administration recovered the histological abnormalities observed in the prostate of BPH rats. In conclusion, these findings support a dose-dependent preventing effect of Lycogen™ on testosterone-induced BPH in rats and suggest that Lycogen™ may be favorable to the prevention and management of benign prostate hyperplasia.
International journal of molecular sciences. 2018 Apr 10*** epublish ***
Chiang-Ting Wang, Ya-Yun Wang, Wen-Sheng Liu, Chun-Ming Cheng, Kuo-Hsun Chiu, Li-Lian Liu, Xue-Zhu Liu, Zhi-Hong Wen, Ya-Huey Chen, Tsung-Ming Chen
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, 70 Lienhai Rd., Kaohsiung 80424, Taiwan. wct5816@gmail.com., Department of Chemistry, Fu Jen Catholic University, New Taipei City 24205, Taiwan. vic0009@gmail.com., Asia-Pacific Biotech Developing, Inc., Kaohsiung 80681, Taiwan. wensheng5394@gmail.com., Department of Animal Pharmacology, Development Centre for Biotechnology, New Taipei City 22180, Taiwan. chunming@dcb.org.tw., Department and Graduate Institute of Aquaculture, National Kaohsiung University of Science and Technology, No.142, Haijhuan Rd., Nazih Dist., Kaohsiung 81157, Taiwan. kuohsun@webmail.nkmu.edu.tw., Department of Oceanography, National Sun Yat-sen University, Kaohsiung 80424, Taiwan. lilian@mail.nsysu.edu.tw., Marine Microorganism Ecological and Application Lab, Zhejiang Ocean University, Zhoushan 316004, China. xuem07@163.com., Department of Marine Biotechnology and Resources, National Sun Yat-sen University, 70 Lienhai Rd., Kaohsiung 80424, Taiwan. wzh@mail.nsysu.edu.tw., Graduate Institute of Biomedical Science, China Medical University, Cancer Center Building 8F, No. 6, Hsueh-shih Road, Taichung 40477, Taiwan. yahuey@mail.cmu.edu.tw., Department and Graduate Institute of Aquaculture, National Kaohsiung University of Science and Technology, No.142, Haijhuan Rd., Nazih Dist., Kaohsiung 81157, Taiwan. tmtonychen@webmail.nkmu.edu.tw.