OBJECTIVE:To examine the association between MUC1 (Ma695) and noninvasive papillary urothelial neoplasm according to the 2004 World Health Organization classification.
STUDY DESIGN: Histologic evaluation was performed in 46 patients with nontumoral benign bladder urothelium (n = 11), papillary urothelial neoplasm of low malignant potential (PUNLMP) (n = 14), low-grade papillary urothelial carcinoma (LgPUC) (n = 11), and noninvasive high-grade papillary urothelial carcinoma (HgPUC) (n = 10). Classical morphologic description and semiquantitative digital measurement were performed from immunohistochemical-stained slides using an anti-MUC1 antibody (Ma695).
RESULTS: Measures showed an obvious statistical difference between benign urothelium and LgPUC (p = 0.0004) or HgPUC (p = 0.0041). MUC1 is expressed less in PUNLMP than in LgPUC (p = 0.04). Benign urothelium and PUNLMP more often showed apical and superficial MUC1 expression. Basal cells with cytoplasmic and/or circumferential membrane positivity were more often observed in LgPUC and HgPUC (p < 0.001).
CONCLUSION: MUC1 could be an interesting tool for the pathologist to differentiate between PUNLMP and LgPUC or HgPUC.
Written by:
Garbar C, Mascaux C. Are you the author?
Department of Biopathology, Institut Jean-Godinot, Centre Régional de Lutte Contre le Cancer, Reims Cedex, France.
Reference: Anal Quant Cytol Histol. 2011 Oct;33(5):277-82.
PubMed Abstract
PMID: 22611755
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