Nutrition, Environmnet and Cancer, Catalana Institute of Oncology, Av Gran via nº199-203, L Hospitalet de Llobregat, Barcelona, 08907, Spain.
Previous epidemiologic studies found inconsistent results for the association between red meat intake, nitrosamines (NDMA: N-Nitrosodimethylamine and ENOC: endogenous nitrosocompounds) and the risk of bladder cancer. We investigated the association between red meat consumption, dietary nitrosamines and heme iron and the risk of bladder cancer among participants of the European Prospective Investigation into Cancer and Nutrition (EPIC).
Data on food consumption and complete follow-up for cancer occurrence were available for a total of 481,419 participants, recruited in 10 European countries. Estimates of hazard ratios were obtained by proportional hazard models, stratified by age at recruitment, gender and study centre, and adjusted for total energy intake, smoking status, lifetime intensity of smoking, duration of smoking, educational level, and BMI
After a mean follow-up of 8.7 years, 1001 participants were diagnosed with bladder cancer. We found no overall association between intake of red meat (log2 HR 1.06; 95% CI: 0.99- 1.13), nitrosamines (log2 HR 1.09; 95% CI: 0.92-1.30 and HR 0.98; 95% CI: 0.92-1.05 for ENOC and NDMA respectively) or heme iron (log2 HR 1.05; 95 CI: 0.99-1.12) and bladder cancer risk. The associations did not vary by sex, high vs. low risk bladder cancers, smoking status or occupation (high vs. low risk).
Our findings do not support an effect of red meat intake, nitrosamines (endogenous or exogenous) or heme iron intake on bladder cancer risk.
Written by:
Jakszyn PG, Gonzalez CA, Lujan Barroso L, Ros MM, Bueno-de-Mesquita HB, Roswall N, Tjonneland AM, Buchner FL, Egevad L, Overvad K, Raaschou-Nielsen O, Clavel-Chapelon F, Boutron-Ruault MC, Touillaud MS, Chang-Claude J, Allen NE, Kiemeney LA, Key TJ, Kaaks R, Boeing H, Weikert S, Trichopoulou A, Oikonomou E, Zylis D, Palli D, Berrino F, Vineis P, Tumino R, Mattiello A, Peeters PH, Parr CL, Gram IT, Skeie G, Sanchez MJ, Larranaga N, Ardanaz E, Navarro C, Rodriguez L, Ulmert D, Ehrnstrom R, Hallmans G, Ljungberg B, Roddam AW, Bingham SA, Khaw KT, Slimani N, Boffetta PA, Jenab M, Mouw T, Michaud DS, Riboli E.
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Reference: Cancer Epidemiol Biomarkers Prev. 2011 Jan 14. Epub ahead of print.
doi: 10.1158/1055-9965.EPI-10-0971
PubMed Abstract
PMID: 21239687
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