The European Association of Urology (EAU), National Comprehensive Cancer Network, and European Society for Medical Oncology guidelines recommend PD-L1 and FGFR testing for patients with locally advanced bladder cancer or upper tract urothelial cancer (UTUC) according to specific eligibility criteria; positive results indicate therapy with immune checkpoint inhibitors or erdafitinib, respectively. The EAU guidelines recommend PD-L1 testing for subsequent adjuvant therapy in high-risk UC, and germline DNA sequencing in patients with UTUC positive for DNA mismatch repair alterations.
European urology. 2024 Sep 11 [Epub ahead of print]
Luca Afferi, Alessia Cimadamore, Andrea Gallioli, Benjamin Pradere, Laura S Mertens, Gautier Marcq, Georgia Anguera, Andrea Necchi, Alberto Briganti, Francesco Montorsi, Morgan Rouprêt, Paolo Gontero, Alberto Breda, Marco Moschini, European Association of Urology Young Academic Urologists Urothelial Carcinoma Working Group
Department of Urology, Fundació Puigvert, Barcelona, Spain; Department of Urology, Luzerner Kantonsspital, Lucerne, Switzerland. Electronic address: ., Institute of Pathological Anatomy, Department of Medicine, University of Udine, Udine, Italy., Department of Urology, Fundació Puigvert, Barcelona, Spain., Department of Urology, UROSUD, La Croix du Sud Hospital, Quint Fonsegrives, France., Department of Urology, Netherlands Cancer Institute, Amsterdam, The Netherlands., Urology Department, Claude Huriez Hospital, CHU Lille, Lille, France; UMR9020-U1277-CANTHER, Institut Pasteur de Lille, Lille University, Lille, France., Department of medical oncology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain., Genitourinary Medical Oncology, IRCCS San Raffaele Hospital and Scientific Institute, Milan, Italy., Department of Urology, San Raffaele Hospital and Scientific Institute, Milan, Italy., GRC 5 Predictive Onco-Uro, Department of Urology, Pitie-Salpetriere Hospital, AP-HP, Sorbonne University, Paris, France., Department of Urology, Città della Salute e della Scienza, University of Torino School of Medicine, Torino, Italy.