The benefits of a robot-assisted radical cystectomy (RARC) compared to an open approach is still under debate. Initial data on RARC were from trials where urinary diversion was performed by an extracorporeal approach, which does not represent a completely minimally invasive procedure. There are now updated data for RARC with intracorporeal urinary diversion that add to the evidence profile of RARC.
To perform a systematic review and meta-analysis of the effectiveness of RARC compared with open radical cystectomy (ORC).
Multiple databases were searched up to May 2022. We included randomised trials in which patients underwent RARC and ORC. Oncological and safety outcomes were assessed.
Seven trials of 907 participants were included. There were no differences seen in primary outcomes: disease progression [RR 0.98, 95% CI 0.78 to 1.23], major complications [RR 0.95, 95% CI 0.72 to 1.24] and quality of life [SMD 0.05, 95% CI -0.13 to 0.38]. RARC resulted in a decreased risk of perioperative blood transfusion [RR 0.57, 95% CI 0.43 to 0.76], wound complications [RR 0.34, 95% CI 0.21 to 0.55] and reduced length of hospital stay [MD -0.62 days, 95% CI -1.11 to -0.13]. However, there was an increased risk of developing a ureteric stricture [RR 4.21, 95% CI 1.07 to 16.53] in the RARC group and a prolonged operative time [MD 70.4 minutes, 95% CI 34.1 to 106.7]. The approach for urinary diversion did not impact outcomes.
RARC is an oncologically safe procedure compared to ORC and provides the benefits of a minimally invasive approach. There was an increased risk of developing a ureteric stricture in patients undergoing RARC that warrants further investigation. There was no difference in oncological outcomes between approaches.
Bladder cancer (Amsterdam, Netherlands). 2023 Sep 25*** epublish ***
Niranjan J Sathianathen, Henry Y C Pan, Marc Furrer, Benjamin Thomas, Philip Dundee, Niall Corcoran, Christopher J Weight, Badrinath Konety, Rajesh Nair, Nathan Lawrentschuk
Department of Surgery, University of Melbourne, Parkville, VIC, Australia., Department of Urology, Royal Melbourne Hospital, Parkville, VIC, Australia., Department of Urology, Cleveland Clinic, Cleveland, OH, USA., Department of Urology, Allina Health, Minneapolis, MN, USA., Department of Urology, Guy's and St Thomas' NHS Foundation Trust, London, UK.