Diuretics remain an important medication for hypertension management among adults with chronic kidney disease (CKD), but diuretics may also worsen urinary symptoms, especially urinary incontinence (UI). This single-center pilot study examined the prevalence of UI among adults age ≥60 years with CKD using diuretics and assessed diuretic avoidance due to urinary symptoms.
Patients with non-dialysis-dependent CKD (estimated glomerular filtration rate <60 ml/min/1.73 m(2)) and diuretic use were recruited from outpatient nephrology clinics. Urinary symptoms and diuretic avoidance were assessed using standardized questionnaires.
The cohort of 44 women and 54 men had a mean age of 71.8 (8.4) years, and urgency-UI, stress-UI and mixed-UI (the presence of both urgency-UI and stress-UI) were reported by 44.9 % (n = 44), 36.7 % (n = 36) and 26.5 % (n = 26), respectively. Nocturia was noted in 68 % (n = 67). Overall, 15.3 % (6 men and 9 women) reported diuretic avoidance. Avoidance of diuretics was 27.3 % (n = 12), 25.5 % (n = 9) and 34.6 % (n = 9) among participants with urgency-UI, stress-UI and mixed-UI, respectively, while only 6.8 % (n = 3) of participants without any UI reported diuretic avoidance. After adjusting for age, sex and diuretic type (loop vs. others), both urgency-UI (odds ratio 5.9 95 % CI 1.5-22.8) and mixed-UI (odds ratio 5.7; 95 % CI 1.6-19.9) were significantly associated with diuretic avoidance compared to participants without urgency-UI, or mixed-UI, respectively. Stress-UI and nocturia were not significantly associated with diuretic avoidance.
UI is common among older adults with CKD receiving diuretics. Patients with urgency-UI are more likely to avoid diuretics.
International urology and nephrology. 2016 May 21 [Epub ahead of print]
Mitul Patel, Kavitha Vellanki, David J Leehey, Vinod K Bansal, Linda Brubaker, Robert Flanigan, Julia Koval, Anuradha Wadhwa, Neelam Balasubramanian, Jasmin Sandhu, Holly Kramer
Division of Nephrology, Department of Medicine, Loyola University Chicago, Stritch School of Medicine, Maywood, IL, USA., Division of Nephrology, Department of Medicine, Loyola University Chicago, Stritch School of Medicine, Maywood, IL, USA., Division of Nephrology, Department of Medicine, Loyola University Chicago, Stritch School of Medicine, Maywood, IL, USA., Division of Nephrology, Department of Medicine, Loyola University Chicago, Stritch School of Medicine, Maywood, IL, USA., Department of Obstetrics and Gynecology, Loyola University Chicago, Stritch School of Medicine, Maywood, IL, USA., Department of Urology, Loyola University Chicago, Stritch School of Medicine, Maywood, IL, USA., Division of Nephrology, Department of Medicine, Loyola University Chicago, Stritch School of Medicine, Maywood, IL, USA., Division of Nephrology, Department of Medicine, Loyola University Chicago, Stritch School of Medicine, Maywood, IL, USA., Clinical Research Office, Loyola University Chicago, Stritch School of Medicine, Maywood, IL, USA., Clinical Research Office, Loyola University Chicago, Stritch School of Medicine, Maywood, IL, USA., Division of Nephrology, Department of Medicine, Loyola University Chicago, Stritch School of Medicine, Maywood, IL, USA. .