to assess health-related quality of life (HRQoL) parameters in patients who received radical cystectomy (RC) with ileal orthotopic neobladder (IONB) reconstruction, and to identify clinic-pathologic predictors of HRQoL.
from January 2010 to December 2013 a multicenter, retrospective study on 174 RC-IONB patients was carried out. All patients completed the following questionnaires including: the European Organisation for Research and Treatment of Cancer (EORTC) generic (QLQ-C30) and bladder cancer-specific instruments (QLQ-BLM30) and the IONB-Patient Reported Outcome (IONB-PRO). Uni and multivariate analyses were computed to identify clinic-pathologic predictors of HRQoL.
Median age was 66 years (range 31-83) and 91.4% of patients were male. Median follow-up period was 37 months (range 3-247). The EORTC QLQ-C30 revealed that age >65 years, absence of urinary incontinence and of peripheral vascular disease were independent predictors of deteriorated body imagine. A follow-up > 36 months and the presence of urinary incontinence were independent predictors of worsened urinary symptoms, while the absence of urinary incontinence was an independent predictor of a worsened body image according to EORTC QLQ-BLM30 results. A follow-up > 36 months and the absence of urinary incontinence were independent predictors of better functioning in terms of relational life, emotional life and fatigue as revealed by the IONB-PRO.
Age, presence of urinary incontinence, length of follow-up, and comorbidity status may influence post-operative HRQoL and should all be taken into account when counseling RC-IONB patients.
Urology 2015 Aug 17 [Epub ahead of print]
Ciro Imbimbo, Vincenzo Mirone, Salvatore Siracusano, Mauro Niero, Maria Angela Cerruto, Cristina Lonardi, Walter Artibani, Pierfrancesco Bassi, Massimo Iafrate, Marco Racioppi, Renato Talamini, Stefano Ciciliato, Laura Toffoli, Francesco Visalli, Davide Massidda, Carolina D'Elia, Giovanni Cacciamani, Davide De Marchi, Tommaso Silvestri, Massimiliano Creta, Emanuele Belgrano, Paolo Verze
Department of Urology - University of Naples Federico II , Department of Urology - University of Naples Federico II , Department of Urology -Trieste University , TESIS Department - Verona University , Department of Urology - Verona University , TESIS Department - Verona University , Department of Urology - Verona University , Department of Urology - Università Cattolica Policlinico Gemelli Roma , Department of Urology - Padua University , Department of Urology - Università Cattolica Policlinico Gemelli Roma , Department of Urology -Trieste University , Department of Urology -Trieste University , Department of Urology -Trieste University , Department of Urology -Trieste University , TESIS Department - Verona University , Department of Urology - Verona University , Department of Urology - Verona University , Department of Urology - Verona University , Department of Urology -Trieste University , Department of Urology - University of Naples Federico II , Department of Urology -Trieste University , Department of Urology - University of Naples Federico II