OBJECTIVES: The URINO trial investigated the effect of offering treatment to older women with urinary incontinence in the general population, who had not sought help on their own initiative.
STUDY DESIGN: In a cluster randomized trial, 14 general practitioners were matched into pairs and randomly allocated to an intervention or a control group. Women aged ≥55 years registered in the participating practices were asked about urinary incontinence via a postal questionnaire. Patients in the intervention group were assessed and treated whereas patients in the control group received standard care.
MAIN OUTCOME MEASURES: Primary outcome was improvement (yes or no) of the severity of symptoms at 12-month follow-up measured with the Incontinence Severity Index. Secondary outcomes were the number of incontinence episodes per day and quality of life. The primary analysis was on an intention-to-treat basis with multiple imputation of missing data. A logistic regression model with correction for cluster randomization was fitted to estimate odds ratios (ORs).
RESULTS: At 12 months, the severity of symptoms had improved in more patients in the intervention group (n166) than in the controls (n184) (OR 1.9; 95% CI 1.1-3.3). Also, the number of patients with fewer episodes of incontinence had increased (OR 2.5; 95% CI 1.5-4.1). No between-group differences in changes in quality of life were apparent (p0.14).
CONCLUSIONS: It is recommended to encourage women in the general population aged ≥55 years with urinary incontinence to undergo diagnosis and treatment.
Written by:
Visser E, de Bock GH, Messelink EJ, Schram AJ, Kollen BJ, Gemert Sl, van den Heuvel ER, Berger MY, Dekker JH. Are you the author?
Department of General Practice, University of Groningen, University Medical Centre Groningen, PO Box 196, 9700 AD Groningen, The Netherlands; Department of Epidemiology, University of Groningen, University Medical Centre Groningen, PO Box 30.001, 9700 RB Groningen, The Netherlands; Department of Urology, University of Groningen, University Medical Centre Groningen, PO Box 30.001, 9700 RB Groningen, The Netherlands; Department of Gynaecology, University of Groningen, University Medical Centre Groningen, PO Box 30.001, 9700 RB Groningen, The Netherlands. ; ; ; ; ; ; ; ;
Reference: Maturitas. 2015 Feb;80(2):212-9.
doi: 10.1016/j.maturitas.2014.11.015
PubMed Abstract
PMID: 25534171