Urgency urinary incontinence (UUI) refractory to medical treatment poses significant challenges despite advancements. This study evaluates the efficacy of intravesical botulinum toxin for UUI and identifies factors influencing treatment outcomes.
Among 368 women receiving botulinum toxin injections, 74.5% achieved a complete discontinuation of pad usage. Predictors of efficacy included lower pre-treatment pad usage and the absence of prior sling placement. Patients often required repeat injections (60.3%), with younger age and satisfaction correlating with treatment repetition. The interval between injections averaged 18 months, influenced by logistical challenges and patient preferences. Despite concerns about diminishing efficacy, subjective perceptions did not align with objective findings. Limitations include retrospective analysis and heterogeneous clinical records. In conclusion, intravesical botulinum toxin is effective for UUI, with pre-treatment pad usage and sling placement history influencing outcomes and patient characteristics influencing treatment repetition.
Toxins. 2024 Jul 26*** epublish ***
Margarida Manso, João Diogo Soares, Margarida Henriques, Francisco Botelho, Carlos Silva, Francisco Cruz
Urology Department, Centro Hospitalar Universitário São João, 4200-319 Porto, Portugal., Faculdade de Medicina da Universidade do Porto, 4200-319 Porto, Portugal.
PubMed http://www.ncbi.nlm.nih.gov/pubmed/39195742