We aimed to investigate the relationship between oxidative stress and LUTS in a community-dwelling population.
The cross-sectional study included 1113 subjects who participated in the Iwaki Health Promotion Project of 2015 in Hirosaki, Japan. LUTS were assessed using structured questionnaires including the International Prostate Symptom Score (IPSS) and the Overactive Bladder Symptom Score (OABSS). IPSS > 7, OABSS > 5, nocturia > 1, or urge incontinence > 1 were defined as moderate to severe symptoms. 8-Hydroxy-2'-deoxyguanosine (8-OHdG) and advanced glycation end products (AGEs) were measured by urine analysis and skin autofluorescence, respectively. The relationship between oxidative stress and LUTS was investigated by logistic regression analyses.
This study included 431 men and 682 women. AGEs and 8-OHdG levels were significantly higher in severe forms of LUTS. Multivariate logistic regression analyses showed that AGE levels were significantly associated with a higher frequency of nocturia but were not associated with IPSS, OABSS, and urge incontinence. No significant association was observed between LUTS and 8-OHdG levels.
AGE levels were significantly associated with nocturia > 1. Further research is necessary to clarify a possible causal relationship between oxidative stress and nocturia. This article is protected by copyright. All rights reserved.
BJU international. 2018 Sep 14 [Epub ahead of print]
Teppei Matsumoto, Shingo Hatakeyama, Atsushi Imai, Toshikazu Tanaka, Kazuhisa Hagiwara, Sakae Konishi, Kazutaka Okita, Hayato Yamamoto, Yuki Tobisawa, Tohru Yoneyama, Takahiro Yoneyama, Yasuhiro Hashimoto, Takuya Koie, Shigeyuki Nakaji, Chikara Ohyama
Department of Urology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan., Department of Advanced Transplant and Regenerative Medicine, Hirosaki University Graduate School of Medicine, Hirosaki, Japan., Department of Urology, Gifu University Graduate School of Medicine, Gifu, Japan., Department of Social Medicine, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.