PURPOSE: Intra-urethral injection of in vitro expanded autologous skeletal muscle-derived cells is a new regenerative therapy for stress urinary incontinence (SUI).
The purpose of the present study was to examine the efficacy and safety of an alternative and simpler strategy using freshly harvested and minced autologous skeletal muscle tissue with its inherent content of regenerative cells.
MATERIALS AND METHODS: 20 women with un-complicated SUI (un-cSUI) and 15 women with complicated SUI (cSUI) received intra-urethral injections of minced autologous skeletal muscle tissue and were followed for one year. Efficacy was assessed by the number of leakages in a three days diary and the scores of the International Consultation on Incontinence Questionnaire - Short Form (ICIQ-SF). Rates of "cure", defined as zero leaks in three days plus an ICIQ-SF score of five or less, and improvement, defined as simultaneous reductions in both outcome measures, were calculated.
RESULTS: Significant reductions were observed in the mean number of leakages (p< 0.01) and in ICIQ-SF scores (P< 0.001) in both groups. In the un-cSUI group, "cure" and improvement were observed in 25% and 63% of the patients respectively, in the cSUI group in 7% and 57% of the patients respectively. No voiding dysfunction developed and only minor adverse events were noted.
CONCLUSIONS: Intra-urethral injection of minced autologous muscle tissue is a simple surgical procedure which appears to be safe and moderately effective for women with un-cSUI and to compare well to a more complicated regenerative strategy using in vitro expanded muscle-derived cells.
Written by:
Gräs S, Klarskov N, Lose G. Are you the author?
Department of Obstetrics and Gynecology, Copenhagen University Hospital Herlev, Herlev Ringvej 75, 2730, Herlev, Denmark.
Reference: J Urol. 2014 Apr 12. pii: S0022-5347(14)03331-X.
doi: 10.1016/j.juro.2014.04.005
PubMed Abstract
PMID: 24735937
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