Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH, 44195, USA.
A significant number of women experience stress urinary incontinence (SUI), which greatly affects their quality of life. Recent research investigating utilization of stem cells and their derivatives for the prevention and treatment of SUI has been performed to test the effect of cell source and method of administration in several animal models of SUI. The type of stem cell, timing of optimal dose or doses after injury, mechanism of action of stem cells, and route of administration must be investigated both preclinically and clinically before stem cell therapy becomes a possible treatment for SUI, although the future of this therapy looks promising. This article reviews the progress in stem cell research for incontinence and describes areas of future work as suggested by research in other fields.
Written by:
Dissaranan C, Cruz MA, Couri BM, Goldman HB, Damaser MS. Are you the author?
Reference: Curr Urol Rep. 2011 Aug 13. Epub ahead of print.
doi: 10.1007/s11934-011-0210-4
PubMed Abstract
PMID: 21842258
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