Department of Obstetrics and Gynecology, Copenhagen University Hospital Herlev, Denmark.
Stress urinary incontinence is a common disorder affecting the quality of life for millions of women worldwide. Effective surgical procedures involving synthetic permanent meshes exist, but significant short and long term complications occur. Cell-based therapy using autologous stem cells or progenitor cells presents an alternative approach, which aims at repairing the anatomical components of the urethral continence mechanism. In vitro expanded progenitor cells isolated from muscle biopsies have been most intensely investigated and both preclinical and a few clinical trials have provided proof of concept for the idea. An initial enthusiasm caused by positive results from early clinical trials has been dampened by the recognition of scientific irregularities. At the same time the safety issue for cell-based therapy has been highlighted by the appearance of new and comprehensive regulatory demands. The influence on the cost effectiveness, the clinical relevance, and the future perspectives of the present clinical approach are discussed.
Written by:
Gräs S, Lose G. Are you the author?
Reference: Acta Obstet Gynecol Scand. 2011 May 12. Epub ahead of print.
doi: 10.1111/j.1600-0412.2011.01184.x
PubMed Abstract
PMID: 21564032
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