Department of Urology, William Beaumont Hospital, Royal Oak, Michigan, USA.
The main urinary continence mechanism in human is the striated muscle rhabdosphincter that forms a ring around the mid-urethra. Cellular therapy and the use of stem cells transplanted into the site of the rhabdosphincter in a setting of stress urinary incontinence (SUI) may augment sphincter regeneration. Implanted cells may also release trophic factors promoting muscle and nerve integration into this muscle. We review the use of cellular therapy for SUI and our experience with the development of muscle-derived stem cells.
Written by:
Nikolavasky D, Stangel-Wójcikiewicz K, Stec M, Chancellor MB.
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Reference: Semin Reprod Med. 2011 Jan;29(1):61-70.
doi: 10.1055/s-0030-1268705
PubMed Abstract
PMID: 21207335
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