To determine if the male responders with post-prostatectomy incontinence in the ADRESU study, which is a clinical trial of regenerative therapy by periurethral injection of adipose-derived regenerative cells, are influenced by any background characteristics.
Briefly, autologous adipose-derived regenerative cells isolated from abdominal adipose tissue and a mixture of adipose-derived regenerative cells with fat tissue were transurethrally injected into the rhabdosphincter and submucosal space of the urethra, respectively. Sixteen out of 43 patients (37.2%) responded to treatment (responders) and exhibited improvement in the urine leakage volume, defined as >50% reduction from baseline determined by the 24-hour pad test at 52 weeks of treatment (or last visit within 52 weeks). Background data such as age, body weight, method of prostatectomy, baseline frequency of leaks, number of leaks, number of pad changes, International Consultation on Incontinence Questionnaire-Short Form, King's Health Questionnaire, urodynamic urethral function including functional profile length and maximum urethral closure pressure, and abdominal leak point pressure were collected and compared between responders and nonresponders.
None of the background factors influenced improvement in the responders as compared with the nonresponders. However, a significant between-group difference in the rates of decrease in urine leakage volume was noted in patients of younger age (<70 years), compared with those of older age (≥70 years) from 2 to 26 weeks of treatment.
A greater decrease in urine leakage volume was noted in the younger patient group than in the older patient group.
Lower urinary tract symptoms. 2022 Feb 25 [Epub ahead of print]
Tomonori Yamanishi, Osamu Ishizuka, Shinobu Shimizu, Yumiko Kobayashi, Fumie Kinoshita, Tokunori Yamamoto, Atushi Mizokami, Kazutaka Narimoto, Kazuhiro Toriyama, Yuzuru Kamei, Yachiyo Kuwatsuka, Masaaki Mizuno, Momokazu Gotoh
Department of Urology, Continence Center, Dokkyo Medical University, Mibu, Japan., Department of Urology, Shinshu University School of Medicine, Matsumoto, Japan., Department of Advanced Medicine, Nagoya University Hospital, Nagoya, Japan., Department of Urology, Nagoya University Graduate School of Medicine, Nagoya, Japan., Department of Integrative Cancer Therapy and Urology, Kanazawa University, Graduate School of Medical Sciences, Kanazawa, Japan., Department of Plastic Surgery, Nagoya City University, Graduate School of Medical Sciences, Nagoya, Japan., Department of Plastic and Reconstructive Surgery, Nagoya University, Graduate School of Medicine, Nagoya, Japan., Japan Community Health Care Organization Chukyo Hospital, Nagoya, Japan.