: Overactive bladder (OAB) is associated with physical, emotional and financial burden. After failed conservative measures, second-line therapy includes medications, such as antimuscarinics and beta-3 adrenergic receptor (β3AR) agonists. Antimuscarinics are most commonly prescribed but have systemic side effects that lead to poor compliance. β3AR agonists include mirabegron and vibegron. Mirabegron is a first generation β3AR agonist that has shown to be effective for frequency, urgency urinary incontinence (UUI) and urgency, but has interactions with cytochrome P450 enzymes (CYPs) and cardiovascular sequelae. Vibegron is a second generation β3AR agonist that is highly selective and does not interact with CYPs. It has shown to be very effective for reducing UUI episodes and daily micturition number and has a favorable side effect profile.
: Clinical background, pharmacology, and clinical studies for vibegron.Expert opinion: Vibegron is a welcomed addition to the OAB therapeutic landscape. This single dose, once daily option is effective, especially for patients with wet OAB, with a favorable side effect profile. Sub-analyses of patients ≥ 65 years have shown continued efficacy and safety. The few drug interactions are of benefit, especially for older patients with polypharmacy. As long-term data accrues, vibegron has the potential to drive the OAB therapeutic market.
Expert opinion on pharmacotherapy. 2022 Sep 20 [Epub ahead of print]
Stephanie Gleicher, Elisabeth M Sebesta, W Stuart Reynolds, Roger Dmochowski
Department of Urologic Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.