No evidence exists regarding the association between smoking status and nocturia among patients with type 2 diabetes mellitus. We evaluated this association among Japanese patients with type 2 diabetes mellitus by post-hoc analysis.
Study subjects were 817 Japanese patients with type 2 diabetes mellitus. Study subjects were considered to have nocturia if they answered "once or more" to the question: "Within one week, how many times do you typically wake up to urinate from sleeping at night until waking in the morning?" We used the following three outcomes: (1) nocturia was ≥1 voids per night; (2) moderate nocturia was ≥2 voids per night; and (3) severe nocturia was ≥3 voids per night. Adjustments were made for age, sex, body mass index, hypertension, dyslipidemia, stroke, glycated hemoglobin, current drinking, use of anti-hypertensive agent, use of insulin, use of oral anti-hyperglycemic agent, and diabetic retinopathy.
The prevalence values of one void per night, two voids per night, and three or more voids per night were 39.5%, 27.1%, and 14.8%, respectively. Current smoking was independently inversely associated with severe nocturia compared with never or former smoking; the adjusted PR was 0.47 (95%CI: 0.25-0.89). Among the 443 patients who had ever smoked, compared with former smoking, current smoking was independently inversely related to severe nocturia; the adjusted PR was 0.44 (95%CI: 0.24-0.82).
In Japanese patients with type 2 diabetes mellitus, current smoking may be independently inversely associated with severe nocturia.
Neurourology and urodynamics. 2016 Aug 26 [Epub ahead of print]
Shinya Furukawa, Takenori Sakai, Tetsuji Niiya, Hiroaki Miyaoka, Teruki Miyake, Shin Yamamoto, Sayaka Kanzaki, Koutatsu Maruyama, Keiko Tanaka, Teruhisa Ueda, Hidenori Senba, Masamoto Torisu, Hisaka Minami, Morikazu Onji, Takeshi Tanigawa, Bunzo Matsuura, Yoichi Hiasa, Yoshihiro Miyake
Department of Epidemiology and Preventive Medicine, Ehime University Graduate School of Medicine, Ehime, Japan., Department of Internal Medicine, Yawatahama General City Hospital, Ehime, Japan., Department of Internal Medicine, Matsuyama Shimin Hospital, Ehime, Japan., Department of Internal Medicine, Saiseikai Matsuyama Hospital, Ehime, Japan., Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Ehime, Japan., Department of Public Health, Juntendo University School of Medicine, Tokyo, Japan., Department of Internal Medicine, Ehime Prefectural Central Hospital, Ehime, Japan., Department of Internal Medicine, Saiseikai Saijo Hospital, Ehime, Japan., Department of Internal Medicine, Ehime Niihama Hospital, Ehime, Japan., Department of Internal Medicine, Saiseikai Imabari Hospital, Ehime, Japan., Department of Lifestyle-Related Medicine and Endocrinology, Ehime University Graduate School of Medicine, Ehime, Japan.