We investigated the efficacy, safety, and impact of desmopressin on quality of sleep in treating nocturnal polyuria in elderly women.
We recruited 60 women over 60 years old with lower urinary tract symptoms (LUTS), including nocturia, and with nocturnal polyuria.
Nocturnal polyuria was defined as nighttime urine production exceeding 33% of the 24-hour total urine volume determined by a frequency volume (FV) chart. All patients failed to respond to treatment of their underlying disease and evening fluid restriction. Desmopressin 0. 1 mg was administered orally at bedtime for 12 weeks. The participants completed a series of questionnaires on the Medical Outcomes Study (MOS) sleep scale and FV chart before and after treatment.
The patient population had a mean age of 69. 2 ± 9. 4 years (range: 61-81). The mean duration of symptoms was 61. 2 ± 45. 1 months. Significant decreases were evident after desmopressin treatment in the number of nocturia episodes (3. 63 ± 1. 61 to 2. 00 ± 1. 13, p = 0. 01), nocturnal urine volume (p = 0. 01), nocturnal polyuria index (NPI) (p = 0. 01), and nocturia index (NI) p = 0. 01). Among the categories of the MOS sleep scale, sleep index (p = 0. 003), sleep disturbance (p = 0. 001), snoring (p = 0. 028), and shortness of breath (p = 0. 036) significantly changed, with a decreased number of nocturia episodes. Adverse events were mild.
Desmopressin is an effective treatment for nocturnal polyuria in elderly women, where conservative treatment has failed. Sleep quality is also improved.
Canadian Urological Association journal = Journal de l'Association des urologues du Canada. 2015 Nov 04 [Epub]
Jong-Hyeon Mun, Sun-Ouck Kim, Ho Song Yu, Ho Suck Chung, Dongdeuk Kwon
Department of Neurosurgery, Kwangju Christian Hospital, Gwangju, South Korea;, Department of Urology, Chonnam National University Medical School, Gwangju, South Korea. , Department of Urology, Chonnam National University Medical School, Gwangju, South Korea. , Department of Urology, Chonnam National University Medical School, Gwangju, South Korea. , Department of Urology, Chonnam National University Medical School, Gwangju, South Korea.