Urination disorders are common in Parkinson's disease (PD) and respond poorly to medication. This study aimed to analyze the risk factors for urination disorders in PD.
Ninety-one patients with PD (aged 34-83 years old) were recruited.
Patients were assessed with the Unified PD Rating Scale (UPDRS), Hoehn and Yahr stage, Pittsburgh Sleep Quality Index (PSQI), Hamilton Depression Rating Scale (HAMD), and Hamilton Anxiety Scale (HAMA). Micturition number was recorded, and Type B ultrasound was used to evaluate residual urine. Statistics was performed using binary logistic regression, bivariate correlations, and Chi-square and t-tests.
Of 91 patients, urinary dysfunction occurred in 55. 0%. Among these, 49. 5% suffered with nocturia, 47. 3% with pollakiuria. Nocturia number had a positive linear relationship with HAMA score (odds ratio [OR] = 0. 340, P = 0. 001), HAMD score (OR = 0. 323, P = 0. 002), duration of L-dopa medication (OR = 0. 328, P = 0. 001), dose of L-dopa (OR = 0. 273, P = 0. 009), UPDRS-II (OR = 0. 402, P = 0. 000), UPDRS-III score (OR = 0. 291, P = 0. 005), and PSQI score (OR = 0. 249, P = 0. 017). Micturition number over 24 h was positively associated with HAMA (OR = 0. 303, P = 0. 004) and UPDRS-II scores (OR = 0. 306, P = 0. 003). Of patients with residual urine, 79. 3% had a volume of residual urine
Nocturia and pollakiuria were common micturition symptoms in our participants with PD. Nocturia was associated with depression, anxiety, sleep problems, and severity of PD. Pollakiuria was associated with anxiety and severity of PD. Male patients were more prone to residual urine and pollakiuria.
Chinese medical journal. 2015 Nov [Epub]
Li-Mei Zhang, Xu-Ping Zhang
Department of Neurology, Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150086, China.