PURPOSE: Many conditions and characteristics are cross-sectionally associated with nocturia.
However, longitudinal associations of frequency-volume chart-based (FVC) nocturia have not yet been studied. We aim to identify [modifiable] determinants of nocturia in older men, in a longitudinal setting.
MATERIAL AND METHODS: A longitudinal, community-based study was conducted among 1,688 men aged 50-78 years in Krimpen aan den IJssel, The Netherlands with planned follow-up rounds at 2, 4 and 6 years. Men without radical prostatectomy, transurethral surgery, or bladder or prostate cancer were included. Data were obtained using FVCs, from which the nocturnal voiding frequency (NVF), maximum voided volume (MVV), and (nocturnal) urine production were determined. Nocturia was defined as NVF ≥2. Polyuria was defined as >2800 ml/24h. For nocturnal polyuria two definitions were used: >33% of the 24-h voided volume (NUV33) and a nocturnal urine production of >90 ml/h (NUP90). Conditions and characteristics were determined via medical examinations and questionnaires. A generalized linear mixed effect model was used to determine factors longitudinally associated with nocturia.
RESULTS: Age (50-55 vs. >60 years), MVV (>300 ml vs. < 300 ml), 24-h polyuria, nocturnal polyuria (both definitions), and LUTS were all longitudinally associated with an increased prevalence of nocturia in older men.
CONCLUSIONS: A smaller MVV, LUTS, 24-h polyuria, and nocturnal polyuria [NP] are significant and potentially modifiable determinants of nocturia. The finding that both definitions for NP are independent significant determinants may point at a two-step etiologic process for NP.
Written by:
van Doorn B, Kok ET, Blanker MH, Westers P, Ruud Bosch JL. Are you the author?
University Medical Center Utrecht, Department of Urology.
Reference: J Urol. 2013 Oct 29. pii: S0022-5347(13)05844-8.
doi: 10.1016/j.juro.2013.10.105
PubMed Abstract
PMID: 24184362
