Although widely viewed as a urological condition, nocturia has been increasingly recognized to accompany various non-urological conditions such as hypertension and blood pressure (BP) elevation on office determination. Home BP monitoring (HBPM) has been shown superior to office-based readings and provides an opportunity to assess potential relationships between nocturia and novel indices derived from multiple BP recordings including BP load, BP variability, and arterial stiffness, which have prognostic significance. We retrospectively studied 103 home BP logs and nocturia frequencies provided by 61 stable cardiology patients ≥ 21 years without medication change. Nocturnal voids ranged from 0 to 5 voids per night, median: 1.5. Nocturia frequency was significantly correlated with home and office systolic BPs and with BP load, but not with diastolic BPs, BP variability or arterial stiffness. On Poisson regression analysis, the estimated prevalence ratio (PR) for home and office systolic BPs were 1.025 (CI: 1.01, 1.04; p < .001) and 1.01 (CI:1.00, 1.02; p = .019), indicating 2.5% and 1% increases in the risk of nocturia per mmHg increases in BP respectively. In conclusion, higher mean home and office systolic BPs are associated with self-reported nocturia frequency with stronger associations seen for home BP measurement. Nocturia frequency appears unrelated to mean home and office diastolic BPs. Nocturia may be related to BP load, (percentage of elevated BP values), but not to BP variability or arterial stiffness. Future prospective studies using HBPM are needed to confirm these findings and to contribute to the understanding of the elevated BP-nocturia link.
Journal of community health. 2022 Nov 12 [Epub ahead of print]
Jason M Lazar, Alexandra Posner, Kamal Akbar, Gulzhan Tologonova, Thomas Monaghan, Christopher Murray, Jeffrey Weiss, Karel Everaert, Tine DeBacker, Elizabeth Helzner, Rose Calixte, Rasheda Browne, Sarah Goldman, Louis Salciccioli
Division of Cardiovascular Medicine, SUNY Downstate Health Sciences University, 450 Clarkson Avenue, MSC 1199, 11203-2098, Brooklyn, NY, USA. ., Division of Cardiovascular Medicine, SUNY Downstate Health Sciences University, 450 Clarkson Avenue, MSC 1199, 11203-2098, Brooklyn, NY, USA., Department of Urology, SUNY Downstate Health Sciences University, Brooklyn, NY, USA., Department of Biostatistics and Epidemiology, School of Public Health, SUNY Downstate Health Sciences University, Brooklyn, NY, USA., Department of Urology, Ghent University Hospital, Ghent, Belgium., Department of Internal Medicine and Pediatrics, Ghent University Hospital, Ghent, Belgium.