Chronic prostatitis (CP) or chronic pelvic pain syndrome (CPPS) is one of the most common diseases in young and middle-aged men, accounting for 30% of outpatient men in urology OPD. There are no definitive diagnostic criteria for CP or CPPS and no accepted therapies that cure the disease.
We identified 372 patients with CP diagnosed from 2015 to 2018 and collect the information of age, routine urinary test, express prostatic secretion (EPS), and NIH-Chronic Prostatitis Symptom Index (NIH-CPSI).
Our study proved a correlation between the increase of prostatic exosomal proteins (PSEPs) level and NIH-CPSI scores. Spearman's correlation coefficient showed a significant level correlation between NIH-CPSI and PSEP level (rs=0.194, P=0.0035). In the meantime, the correlation was found between the PSEP level and EPS-white blood cells. Spearman's correlation coefficient showed that there was a significant hierarchical correlation between EPS-white blood cells and PSEP level (rs=0.183, P=0.001).
These findings highlight the potential of PSEP is a practical indicator of the symptomatic progression of CP/CPPS. Applications of PSEP assay may guide drug discovery and lead to better treatment to improve the patient's quality of life.All in all, PSEP detection in urine is safe and effective, and it is worthy of further promotion and application in clinical practice.
Translational andrology and urology. 2020 Oct [Epub]
Weining Liang, Zhigang Wu, Guowei Zhang, Weikang Chen, Xiangnong Hu, Jianjun Yang, Jie Meng, Yan Zeng, Hongjun Li, Xuejun Shang
Department of Andrology, Jinling Hospital, The First School of Clinical Medicine, Southern Medical University, Nanjing, China., Department of Urology, Suqian First Hospital, Suqian, China., Department of Andrology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China., Onco Biomedical Technology (Suzhou) CO. LTD, Taicang, China., Department of Immunology, Jinan Military General Hospital, Jinan, China., Urological Department of Peking Union Medical College Hospital (PUMCH), Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.