Collagen fleece grafting (CFG) is the recommended treatment for severe Peyronie's disease (PD) curvature (> 60°), but its efficacy in mild/moderate curvatures remains uncertain. This study evaluated CFG in patients with mild/moderate curvatures (< 60°) at risk of penile shortening or symptomatic plaque.
A retrospective review was conducted on patients who underwent surgical treatment for PD using plaque incision or partial plaque excision and CFG. Clinical parameters and complications were reviewed. Subgroup analysis was performed on patients with curvatures of > 60° and curvatures ≤ 60°.
89 patients with a median age of 59 years and a median curvature of 70 (20-90)° were identified. Dorsal curvature was predominant in 66% of cases, followed by lateral (16%), ventral (8%), and complex curvatures (10%). Partial plaque excision was performed in 98% of patients, with an average grafting area of 2.1 cm2; 71% had a singular penile plaque, while 29% presented two or more plaques. The comparison between patients with curvatures ≤ 60° and > 60° revealed no significant differences in mean operation time (86.3 vs. 94.4 min, p = 0.13) or in the incidence of postoperative complications, including glans necrosis, hypoesthesia, ecchymosis, bleeding, hematoma, infection, residual curvature, revision surgery, or pain.
Early postoperative outcomes and complication rates following plaque incision or partial plaque excision and grafting with CFG were comparable in patients with mild/moderate and severe PD deformities. The technique may be a viable option with a similar risk profile for achieving penile straightening in selected PD cases, particularly when plication is not feasible.
International urology and nephrology. 2024 Oct 08 [Epub ahead of print]
Radion Garaz, Bastian Amend, Arnulf Stenzl, Jens Bedke, Jörg Hennenlotter, Alexander Rochwarger, Christian M Schürch, Igor Tsaur, Steffen Rausch
Department of Urology, Eberhard Karls University of Tübingen, Hoppe-Seyler-Straße 3, 72076, Tübingen, Germany. ., Department of Urology, Eberhard Karls University of Tübingen, Hoppe-Seyler-Straße 3, 72076, Tübingen, Germany., Department of Urology and Transplantation Surgery, Stuttgart Hospital, Stuttgart, Germany., Department of Pathology and Neuropathology, Eberhard Karls University of Tübingen, Tübingen, Germany.