OBJECTIVE: To evaluate the risk of male infertility among patients with hepatitis B virus (HBV) infection.
DESIGN: A nationwide, population-based cohort study.
SETTING: Not applicable.
SETTING: PATIENT(S):Men infected with HBV (n = 5,138) and men without HBV infection (n = 25,690).
INTERVENTION(S): None.
MAIN OUTCOME MEASURE(S): Male infertility, as defined by the International Classification of Diseases, Ninth Revision, Clinical Modification.
RESULT(S): The incidence of infertility was 1.59 times higher in patients with HBV infection than in those without HBV infection (2.21 vs. 1.39 per 1,000 person-years). The risk of developing infertility remained significant among patients with HBV infection (hazard ratio 1.52, 95% confidence interval 1.20-1.92) after adjusting for covariates in a multivariate Cox proportional hazards model.
CONCLUSION(S): The data show an increased incidence and risk of infertility among men with HBV infection compared with men without HBV.
Written by:
Su FH, Chang SN, Sung FC, Su CT, Shieh YH, Lin CC, Yeh CC. Are you the author?
Department of Family Medicine, Taipei Medical University Hospital, Taipei, Taiwan; Department of Family Medicine, School of Medicine, Taipei Medical University, Taipei, Taiwan; PhD Program for Cancer Biology and Drug Discovery, China Medical University, Taichung, Taiwan; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan; Management Office for Health Data, China Medical University, Taichung, Taiwan; Management Office for Health Data, China Medical University, Taichung, Taiwan; Department of Public Health, China Medical University, Taichung, Taiwan; School of Public Health, College of Public Health and Nutrition, Taipei Medical University, Taipei, Taiwan; Department of Family Medicine, School of Medicine, Taipei Medical University, Taipei, Taiwan; Department of Family Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan; Division of Family Medicine, China Medical University, Taichung, Taiwan; Department of Public Health, China Medical University, Taichung, Taiwan; School of Public Health, College of Public Health and Nutrition, Taipei Medical University, Taipei, Taiwan.
Reference: Fertil Steril. 2014 Dec;102(6):1677-84.
doi: 10.1016/j.fertnstert.2014.09.017
PubMed Abstract
PMID: 25439807