BACKGROUND: This study was conducted to assess reproductive endocrine function, testicular volume, semen quality, and fertility in adult male patients after renal transplantation (RTx) during childhood or adolescence.
METHODS: Twenty-four RTx recipients (median age: 28.1 years) were examined at a median of 18.6 years after RTx. Reproductive hormone levels and semen samples were studied and compared to those of 56 age-matched controls (median age: 30.2 years). Eight RTx men (33%) had been treated with cyclophosphamide. Medical records were retrospectively reviewed and data on puberty, dialysis, and immunosuppressive medication were analyzed to evaluate the prospect of fertility and sexual health.
RESULTS: The testicular volumes and total sperm counts of the RTx patients were smaller than those of the controls with a median of 11.4 versus 33.9 mL, P< 0.001 and 1.3 versus 135.5 million, P< 0.001, respectively. Only four (22%) of the RTx men had normospermia in semen sample. The reproductive hormone levels were normal in the majority of the RTx survivors, with only two survivors showing androgen deficiency. Patients without history of cyclophosphamide therapy had significantly smaller testes and total sperm counts (median: 12.5 mL and 16.3 million) in comparison with their healthy peers (P< 0.001 in both), and those with previous cyclophosphamide treatment showed further worse outcome (8.5 mL and 0 million, respectively, P< 0.001 in both).
CONCLUSIONS: Testicular function is often impaired even years after transplantation and poor semen quality decreases the prospect of fertility in men after pediatric RTx.
Written by:
Tainio J, Jahnukainen K, Nurmio M, Pakarinen M, Jalanko H, Jahnukainen T. Are you the author?
Children's Hospital, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland; Department of Physiology and Pediatrics, University of Turku, Turku, Finland; Children's Hospital, Biomedicum Helsinki 2C, PO Box 705, Helsinki FI-00290, Finland.
Reference: Transplantation. 2014 May 12. Epub ahead of print.
doi: 10.1097/TP.0000000000000173
PubMed Abstract
PMID: 24825526
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