There has been a growing interest over the past few years in the impact of male nutrition on fertility.
Infertility has been linked to male overweight or obesity, and conventional semen parameter values seem to be altered in case of high body mass index (BMI). A few studies assessing the impact of BMI on sperm DNA integrity have been published, but they did not lead to a strong consensus. Our objective was to explore further the relationship between sperm DNA integrity and BMI, through a 3-year multicentre study. Three hundred and thirty male partners in subfertile couples were included. Using the terminal uridine nick-end labelling (TUNEL) assay, we observed an increased rate of sperm DNA damage in obese men (odds ratio (95% confidence interval): 2.5 (1.2-5.1)).
Written by:
Dupont C, Faure C, Sermondade N, Boubaya M, Eustache F, Clément P, Briot P, Berthaut I, Levy V, Cedrin-Durnerin I, Benzacken B, Chavatte-Palmer P, Levy R. Are you the author?
AP-HP, Jean Verdier hospital, Reproductive Biology unit-CECOS, F-93140 Bondy, France; Paris 13 University, Sorbonne Paris Cité, Nutritional epidemiology unit (UREN, UMR U557 Inserm, U1125 Inra, Cnam, CRNH IdF), F-93017 Bobigny, France; INRA, UMR1198 Biologie du Développement et Reproduction (Biology of Reproductive and development unit), F-78352 Jouy en Josas, France; ENVA, veterinary school, F-94704 Maisons-Alfort, France.
Reference: Asian J Androl. 2013 Jun 24. Epub ahead of print.
doi: 10.1038/aja.2013.65
PubMed Abstract
PMID: 23792341
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