Follicle-stimulating hormone (FSH) treatment has been proven effective in stimulating spermatogenesis and improving the reproductive ability of men with hypogonadotropic hypogonadism, while the usefulness of such a treatment in infertile patients with normal pituitary function is restricted to a subgroup of responders that, however, cannot be identified by the current diagnostic tools before treatment.
In this review we summarize the role played by FSH in the modulation of spermatogenesis, the effect of FSH treatment at a standard replacement dose and at higher dose on sperm parameters, spontaneous and in vitro fertilization pregnancy rates, and the efforts made to identify possible responders to FSH treatment.
Fertility and sterility. 2022 Dec 02 [Epub ahead of print]
Ettore Caroppo, Craig S Niederberger
Asl Bari, Reproductive Unit, Andrology Outpatients Clinics, Conversano, Italy. Electronic address: ., Department of Urology, University of Illinois at Chicago, Chicago, Illinois; Department of Bioengineering, University of Illinois at Chicago College of Engineering, Chicago, Illinois.
PubMed http://www.ncbi.nlm.nih.gov/pubmed/36470702