The inability to conceive due to male infertility is a complex issue with a wide variety of etiologies. Sperm DNA damage can be both a barrier to natural pregnancy and successful assisted reproductive technology (ART). The aim of this narrative review was to describe and highlight the effects of sperm DNA fragmentation and the most recent data on various treatment strategies to decrease sperm DNA damage. Finally, we proposed a management algorithm for couples undergoing ART with increased sperm DNA fragmentation.
Urology. 2022 Jun 12 [Epub ahead of print]
Justin Loloi, Francis Petrella, Eliyahu Kresch, Emad Ibrahim, Armand Zini, Ranjith Ramasamy
Department of Urology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY 10461., Department of Urology, McGill University, Montreal, Canada., Department of Urology, Miller School of Medicine, University of Miami, Miami, FL 33136., Department of Urology, Miller School of Medicine, University of Miami, Miami, FL 33136. Electronic address: .