Infertility is a common problem in testicular cancer. Affected men often decide to undergo sperm banking before chemo/radiotherapy. The cumulative effects of therapy can considerably reduce fertility.
Testicular cancers impair fertilizing ability, even before diagnosis. This study tries to verify individual traits and semen quality in patients with testicular cancer.
This observational study analyzed 190 semen of patients with testicular cancer (16 to 47 yr old) referred to the sub-fertility laboratory at the St. Mary hospital for semen banking prior to treatment carcinoma. Several aspects of their semen analyses were examined. The cases were divided into four different categories: seminoma, teratoma, mixed germ cell tumors and others.
The results showed that 23 cases were azoospermic, and 13 of the patients who were not azoospermic, their sperm of "normal" morphology were too few to count. Among patients that could produce spermatozoa, 59.4% had a sperm concentration of < 20 × 10 6 /ml. The mean of "motility excellent" and "sluggish" taken together in all the cases was 47.2%. More than 92% of the patients had an abnormal morphology. The morphology of sperm is the most sensitive semen parameter that is affected by testicular carcinoma.
Abnormal spermatogenesis is seen in most patients with testicular cancer before treatment with radiation, chemotherapy, or surgery. The causes of poor semen quality in cancer patients are not well-understood, but the patients with impaired spermatogenesis should have precise examination to find out the correct diagnosis of problem and preserve the fertility before any treatment.
International journal of reproductive biomedicine (Yazd, Iran). 2020 Jul 22*** epublish ***
Behrooz Ghasemi, Alimohammad Mosadegh Mehrjardi, Carolyn Jones, Nasrin Ghasemi
Maternal and Fetal Health Research Centre, Division of Developmental Biology and Medicine, Reproductive Medicine, School of Medical Sciences, St Mary's Hospital, University of Manchester, Manchester, UK., Division of Developmental Biology and Medicine, Maternal and Fetal Health Research Centre, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Central Manchester University Hospital NHS Foundation Trust, Manchester Academic Health Sciences Centre, St Mary's Hospital Manchester, UK., Abortion Research Centre, Reproductive Sciences Institute, Shahid Sadoughi University of Medical Science, Yazd, Iran.