We investigated changes in the levels of adenosine triphosphate (ATP) and nitric oxide (NO) in the urothelium of detrusor underactivity (DU) with benign prostatic hyperplasia (BPH).
We prospectively enrolled 30 men who planned to undergo surgical treatment for BPH. Patients whose bladder contractility index (BCI) was less than 100 were assigned to the DU group (n = 15), while patients whose BCI was more than 100 were assigned to the no DU group (n = 15). Bladder mucosal specimens were collected during surgical prostate resection, and ATP and eNOS were analyzed from these specimens. The levels of ATP and eNOS were compared between the two groups. The correlation of urodynamic parameters with ATP and eNOS in all patients were assessed.
The level of eNOS was not significantly different between the DU and no DU groups (3.393 ± 0.969 vs. 1.941 ± 0.377 IU/ml, P = 0.247). However, the level of ATP in the DU group was significantly lower than that in the no DU group (1.289 ± 0.320 vs. 9.262 ± 3.285 pmol, P = 0.011). In addition, ATP was positively correlated with BCI (r = 0.478, P = 0.018) and detrusor pressure on maximal flow (r = 0.411, P = 0.046) in all patients.
ATP in urothelium was significantly decreased in DU with BPH and reflects the change in detrusor function.
The Journal of urology. 2017 Jun 24 [Epub ahead of print]
Kang Jun Cho, Jun Sung Koh, Jinbong Choi, Joon Chul Kim
Department of Urology, Bucheon St. Mary`s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea., Department of Urology, Bucheon St. Mary`s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea. Electronic address: .