To compare the efficacies of naftopidil and tamsulosin in terms of reducing storage symptoms in patients with BPH.
This prospective randomized study was performed at 10 centers. Ninety-four patients that had been taking tamsulosin for more than 8 weeks, but had an OABSS of greater than 3 points were initially enrolled. After a 1 week washout period, patients were divided into two groups. Forty-five patients were treated with tamsulosin 0.2 mg daily and 49 patients were treated with naftopidil 75 mg daily for 8 weeks, respectively. Total IPSS, storage symptom scores, nocturia times, OABSS, maximal flow rates (Qmax), and post-void residual volumes (PVR) were checked before and after the 8-week treatment period.
Mean patient ages in the tamsulosin and naftopidil groups were 64.8 and 66.0 years, respectively. Baseline characteristics were not significantly different. In tamsulosin group, mean total IPSS fell from 19.1 to 15.1 after the 8-week treated period (p=0.001), and in naftopidil group, mean total IPSS fell from 16.9 to 13.1(p=0.001). Mean storage symptom scores reduced in tamsulosin and naftopidil groups from 8.0 to 6.6 (p=0.002) and from 7.6 to 6.1 (p=0.001), respectively. Mean nocturia times in naftopidil groups decreased significantly from 2.5 to 1.9, respectively (p=0.001), and mean OABSS reduced from 7.7 to 6.0 (p=0.001) and from 7.4 to 6.0, respectively (p=0.001).
Total IPSS, storage symptom scores, nocturia times and OABSS were significantly more reduced by naftopidil and tamsulosin. Moreover, the naftopidil group showed better improvements in nocturia than tamsulosin group.
Urology. 2017 Jun 14 [Epub ahead of print]
Se Yun Kwon, Kyung Seop Lee, Tag Keun Yoo, Jae Il Chung, Ji Youl Lee, Jun Hyuk Hong, Seong Il Seo, Tae Young Jung, Cheol Kwak, Taek Won Kang, Seok-Joong Yun
Department of Urology, Dongguk University College of Medicine, Gyeongju, Korea., Department of Urology, Dongguk University College of Medicine, Gyeongju, Korea. Electronic address: ., Department of Urology, Eulji General Hospital, Seoul, Korea., Department of Urology, Inje University Busan Paik Hospital, Busan, Korea., Department of Urology, Catholic University College of Medicin, Seoul, Korea., Department of Urology, Asan Medical Center, Ulsan University College of Medicine, Seoul, Korea., Department of Urology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea., Department of Urology, Veterans Health Service Medical Center, Seoul, Korea., Department of Urology, Seoul National University Hospital, Seoul, Korea., Department of Urology, Chonnam National University Medical School, Gwangju, Korea., Department of Urology, Chungbuk National University Hospital, Chungbuk National University College of Medicine, Cheongju, Korea.