Elevated iron, high-sensitivity C-reactive protein (CRP) and hypoadiponectinemia are known to initiate tumour development. There is paucity of data regarding the above-mentioned parameters and their relation with prostate size in benign prostatic hyperplasia (BPH). The present study was designed to assess the levels of iron, hs-CRP and adiponectin levels and their association with prostate size in BPH patients. A total of 37 BPH cases and 36 controls were enrolled in the study. Iron, hs-CRP and adiponectin were estimated in both the groups. Iron and hs-CRP were significantly increased and adiponectin was significantly reduced in BPH cases when compared with controls. Iron (r = .397, p = .015), hs-CRP (r = .341, p = .039) and adiponectin (r = -.464, p = .004) were significantly associated with prostate size in BPH cases. Multivariate linear regression analysis showed that iron acts as predictor of prostate size in BPH (R(2) = 0.395, β = 0.526, p = .001). We conclude that iron and hs-CRP are elevated and adiponectin is reduced in BPH cases and associated with prostate size.
Andrologia. 2016 Sep 23 [Epub ahead of print]
H Nandeesha, A Eldhose, L N Dorairajan, B Anandhi
Department of Biochemistry and Urology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India. nandijipmer@gmail.com., Department of Biochemistry and Urology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.