We evaluated the effects of Seoritae extract (SE) on mild to moderate lower urinary tract symptoms (LUTS) suggestive of benign prostatic hyperplasia (BPH). Seventy-six subjects with mild to moderate LUTS suggestive of BPH were prospectively recruited from the urology outpatient clinic and assigned to either SE (4200 mg or 6 tablets 3 times a day) or matching placebo. The primary outcome variable, the International Prostatic Symptom Score (IPSS), was evaluated at baseline and at 4 and 12 weeks. Postvoid residual volume (PVR), maximum urine flow rate (Q max), and prostate-specific antigen (PSA) levels were evaluated. IPSSs decreased significantly from baseline to 12 weeks within the SE group. Significant improvements in IPSS voiding scores at 4 and 12 weeks were also observed in the SE group compared to the placebo group. IPSS storage and quality of life scores were also significantly decreased at 12 weeks in the SE group. There was no change in Q max or PVR in both groups after 12 weeks. Administration of SE for 12 weeks led to significant improvements in LUTS, and it can be concerned as a reasonable and safe alternative for men with mild to moderate LUTS.
Evidence-based complementary and alternative medicine : eCAM. 2016 Jun 13 [Epub]
Woong Jin Bae, Hyo Jung Park, Hye Cheong Koo, Do Ram Kim, U-Syn Ha, Kang Sup Kim, Su Jin Kim, Hyuk Jin Cho, Sung Hoo Hong, Ji Youl Lee, Sung Yeoun Hwang, Sae Woong Kim
Catholic Integrative Medicine Research Institute, College of Medicine, The Catholic University of Korea, Seoul 137-701, Republic of Korea; Department of Urology, College of Medicine, The Catholic University of Korea, Seoul 137-701, Republic of Korea., Department of Urology, College of Medicine, The Catholic University of Korea, Seoul 137-701, Republic of Korea., Korea Bio Medical Science Institute, Seoul, Republic of Korea., Korea Bio Medical Science Institute, Seoul, Republic of Korea., Department of Urology, College of Medicine, The Catholic University of Korea, Seoul 137-701, Republic of Korea., Department of Urology, College of Medicine, The Catholic University of Korea, Seoul 137-701, Republic of Korea., Department of Urology, College of Medicine, The Catholic University of Korea, Seoul 137-701, Republic of Korea., Department of Urology, College of Medicine, The Catholic University of Korea, Seoul 137-701, Republic of Korea., Department of Urology, College of Medicine, The Catholic University of Korea, Seoul 137-701, Republic of Korea., Department of Urology, College of Medicine, The Catholic University of Korea, Seoul 137-701, Republic of Korea., Korea Bio Medical Science Institute, Seoul, Republic of Korea., Catholic Integrative Medicine Research Institute, College of Medicine, The Catholic University of Korea, Seoul 137-701, Republic of Korea; Department of Urology, College of Medicine, The Catholic University of Korea, Seoul 137-701, Republic of Korea.