OBJECTIVES - To assess the efficacy of dutasteride add-on therapy for patients with benign prostatic hyperplasia (BPH) and lower urinary tract symptoms (LUTS) with small prostates who have been treated with α-blocker therapy for >3 months.
METHODS - A total of 110 men with clinical BPH were enrolled. There were 17 and 93 subjects with a prostate volume (PV) 3 months. Subjective and objective clinical variables were assessed using the total International Prostate Symptom Score (IPSS-T), IPSS quality of life (IPSS-QoL), IPSS voiding subscore (IPSS-V), IPSS storage subscore (IPSS-S), overactive bladder symptom score (OABSS), PV, prostate specific antigen (PSA) level, post-void residual (PVR), and maximum flow rate (Qmax). These variables were assessed at baseline and every 3 months for 1 year.
RESULTS - In the small prostate group, IPSS-T and IPSS-V showed improvements from baseline at 6 and 9 months, storage subscore at 6 months, and OABSS at 3 months, but no sustained improvements were observed. During the study period, only the IPSS QoL scores did not show any improvement. Conversly, dutasteride was significantly effective at improving IPSS-T, IPSS-V, IPSS-S, and IPSS-QoL scores throughout the study period in the large prostate BPH group. PSA levels and PV significantly decreased in both groups throughout the study.
CONCLUSIONS - Benign prostatic hyperplasia in LUTS patients with small prostates did not show a sustainable benefit from the addition of dutasteride to α-blocker therapy.
Lower urinary tract symptoms. 2016 Mar 16 [Epub ahead of print]
Mamoru Hashimoto, Nobutaka Shimizu, Koichi Sugimoto, Sachiko Hongoh, Takafumi Minami, Masahiro Nozawa, Kazuhiro Yoshimura, Akihide Hirayama, Hideo Tahara, Hirotsugu Uemura
Department of Urology, Kinki University Faculty of Medicine, Osaka-Sayama, Japan., Department of Urology, Kinki University Faculty of Medicine, Osaka-Sayama, Japan., Department of Urology, Kinki University Faculty of Medicine, Osaka-Sayama, Japan., Department of Urology, Kinki University Faculty of Medicine, Osaka-Sayama, Japan., Department of Urology, Kinki University Faculty of Medicine, Osaka-Sayama, Japan., Department of Urology, Kinki University Faculty of Medicine, Osaka-Sayama, Japan., Department of Urology, Kinki University Faculty of Medicine, Osaka-Sayama, Japan., Department of Urology, Nara Hospital Kinki University Faculty of Medicine, Ikoma, Japan., Department of Urology, Mimihara General Hospital, Sakai, Japan., Department of Urology, Kinki University Faculty of Medicine, Osaka-Sayama, Japan.