Benign prostatic hyperplasia (BPH) is a common disease in older men that involves the enlargement of the prostate gland. This occurs in response to signal transduction initiated by α-adrenergic receptors (α-ARs).
When bound to ligands, α-AR stimulate the mitogenic extracellular signal-regulated kinases 1 and 2 (ERK) pathway, ultimately promoting stromal and epithelial cell hyperplasia in the prostate. Current knowledge of how α-ARs promote prostate cell growth remains incomplete, and despite decades of research, there is no cure for BPH. In this study, we aimed to exploit an in vitro model system of BPH in order to better understand the mechanisms of α-AR signaling in prostatic hyperplasia.
Biochemical and biophysical research communications. 2016 Feb 02 [Epub ahead of print]
Mindy Wang, Yehia Daaka, Anindya Dey
Department of Anatomy and Cell Biology, University of Florida College of Medicine, Gainesville, FL, USA. , Department of Anatomy and Cell Biology, University of Florida College of Medicine, Gainesville, FL, USA. , Department of Anatomy and Cell Biology, University of Florida College of Medicine, Gainesville, FL, USA; Department of Obstetrics and Gynecology, Stephenson Cancer Center, University of Oklahoma Health Science Center, Oklahoma City, OK, USA.