To investigate the effect of tamsulosin on LUTS and depressive symptoms among depressed and non-depressed individuals previously diagnosed with BPH.
The study conducted from July 2013 to June 2014 that included outpatient participants with BPH presenting with LUTS.
Tamsulosin 0. 2mg 1 tablet was administered to patients daily. We divided participants with geriatric depression scale (GDS) scores of 0-17 into the non-depressive symptom group (Group 1) and those with GDS scores of 18-30 into the depressive symptom group (Group 2). At the first visit (V1), 4(th) week (V2), and 12(th) week (V3), the international prostate symptom score (IPSS), quality of life (QoL), patient perception of bladder condition (PPBC), overactive bladder syndrome symptom score (OABSS), and GDS questionnaires were administered.
IPSS (17. 35±7. 11 vs. 14. 61±6. 04, p=0. 10) as well as GDS scores (20. 97±3. 07 vs. 8. 84±4. 50, p<0. 01) were higher among those with depressive symptoms than those without and difference between the two groups was not represented. After taking tamsulosin, on the V2and V3, both groups showed improved scores in OABSS, PPBC, IPSS, QoL, and GDS Comparing the first visit with the V2and V3, Group 2 showed significant changes in GDS, but not group 1.
Treatment with tamsulosin is associated with improved LUTS and decreased depressive symptoms, which could enhance quality of life.
Urology. 2015 Oct 22 [Epub ahead of print]
Kyu Shik Kim, Eun Young Jang, Yong Tae Kim, Hong Sang Moon
Department of Urology, Hanyang University College of Medicine, Seoul, Korea. , Department of Psychiatry, Hanyang University Guri Hospital, Guri, Korea. , Department of Urology, Hanyang University College of Medicine, Seoul, Korea. , Department of Urology, Hanyang University College of Medicine, Seoul, Korea.