Transurethral dilatation of the prostate (TUDP) with a spherical balloon catheter is a traditional treatment to benign prostatic hyperplasia (BPH) patients.
However, TUDP has been abandoned in clinical application because of its unsatisfying treatment benefit and severe complications. In this study, we redesigned an improved TUDP surgery, named transurethral split of the prostate (TUSP), by replacing the spherical balloon with a columnar balloon. To evaluate the clinical therapeutic effect, we compared the lower urinary tract symptoms (LUTS) of BPH patients after TUSP treatment and analyzed the urethra through CT films. Animal experiments were performed on aged dogs to investigate the urine function and electromyography (EMG) changes. Histopathology was used to evaluate the inflammation and injury. Additionally, collagen content was detected by Trichrome Masson. TUSP attenuated LUTS and reconstructed urethra in BPH patients. The attenuation of LUTS was reflected in terms of LUTS parameters such as Qmax, post-void residual urine volume (PVR), quality of life (QOL) score and International Prostate Symptom Score (IPSS). TUSP expanded the urethra in experimental dogs by splitting the prostate tissues and decreasing the collagen content, with maintenance of normal urinary function and EMG characteristics. The successful clinical application of TUSP with significant therapeutic effect and limited complications made TUSP an ideal choice for the BPH patients.
Written by:
Huang W, Guo Y, Xiao G, Qin X. Are you the author?
Drum Tower Hospital of Nanjing University, Urinary Surgery, No.321 Zhongshan Road, Nanjing, China, 210008.
Reference: J Endourol. 2014 Oct 6. Epub ahead of print.
doi: 10.1089/end.2014.0207
PubMed Abstract
PMID: 25285775