Association between metabolic syndrome and severity of lower urinary tract symptoms: Observational study in a 4,666 European men cohort - Abstract

OBJECTIVES: To evaluate the relationship between metabolic syndrome (MS) and the frequency and severity of lower urinary tract symptoms (LUTS).

PATIENTS AND METHODS: 4,666 male patients from 55 to 100 years old consulting a general practitioner (GP) on a 12-days period in December 2009 have been included into an observational study. LUTS were defined according to the I-PSS score and metabolic syndrome with the NECP/ATP III definition. We studied the correlation between MS and its individual component, and the severity of LUTS (I-PSS and treatment for LUTS). Analyses were adjusted on BMI, age, and PSA level.

RESULTS: MS was reported in 51.5 % of the patients and 47% were treated for LUTS. There was a significant link between MS and treated LUTS (p< 0.001). The risk to be treated for LUTS also increased with increasing number of MS components present. MS was positively correlated with the severity of the LUTS (p< 0.001) in term of overall I-PSS score and both voiding and storage scores (p< 0.001). Each component of the MS (except HDLc) appeared as an independent risk factor of high I-PSS and of LUTS treatment in multivariate analysis. MS was positively correlated with prostate volume.

CONCLUSIONS: Our results suggest a significant relationship between LUTS linked to BPH and MS, in terms of frequency and severity. The risk to be treated for LUTS also increased with increasing number of MS components present. The prevention of such modifiable factors by the promotion of dietary changes and regular physical activity practice may be of great interest for public health.

Written by:
Pashootan P, Ploussard G, Cocaul A, De Gouvello A, Desgrandchamps F.   Are you the author?
Urology Department, APHP, Saint-Louis Hospital, 75475 Paris Cedex 10, France.

Reference: BJU Int. 2014 Sep 17. Epub ahead of print.
doi: 10.1111/bju.12931


PubMed Abstract
PMID: 25229124

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