PURPOSE: To examine the cross-sectional associations between baseline characteristics and sexual function and the longitudinal associations between change in lower urinary tract symptoms (LUTS) and change in sexual function among men with benign prostatic hyperplasia (BPH).
MATERIALS AND METHODS: We studied LUTS assessed by the American Urological Association symptom index and sexual function determined by the Brief Male Sexual Function Inventory (BMSFI) in men enrolled in the Medical Therapy of Prostatic Symptoms (MTOPS) Study. The cross-sectional cohort included 2,916 men who completed the BMSFI at baseline. The longitudinal cohort included 672 men who were randomized to placebo and had completed the BMSFI at baseline and at least once during a four year follow-up. Multiple adjusted linear modeling for each domain of the BMSFI was performed to assess associations of sexual function with LUTS.
RESULTS: After adjustment for baseline demographic and clinical characteristics, increased age, less education, obesity, and severe LUTS each was significantly associated with poorer sexual drive, erectile function, ejaculatory function, sexual problem assessment, and overall satisfaction in the cross-sectional cohort. However, none of these baseline characteristics predicted change in sexual function in the longitudinal cohort. Decline in sexual function in all sexual function domains associated with worsening of LUTS in this group was small.
CONCLUSIONS: Increased age, less education, obesity, and more severe LUTS were individually associated cross-sectionally, but not longitudinally, with poorer sexual function in men with LUTS/BPH. The decline in sexual function associated with worsening of LUTS in men assigned to placebo was small.
Written by:
Fwu CW, Kirkali Z, McVary KT, Burrows PK, Eggers PW, Kusek JW. Are you the author?
Social & Scientific Systems, Inc., Silver Spring, MD; Division of Kidney, Urologic and Hematologic Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD; Division of Urology, Southern Illinois University School of Medicine, Springfield, IL; The George Washington University Biostatistics Center, Rockville, MD.
Reference: J Urol. 2014 Aug 20. pii: S0022-5347(14)04260-8.
doi: 10.1016/j.juro.2014.08.086
PubMed Abstract
PMID: 25150638