Background: Benign prostatic hyperplasia is one of the most common conditions in middle-aged and elderly males.
Aim Of The Study: Investigate the biological effects and changes in the levels of relevant cellular factors and to elucidate the possible mechanism underlying the effects of low-frequency ultrasound combined with microbubble agents.
Methods: Eighteen Male Beagle canines were divided into six groups randomly: Control group, 21kHz ultrasonic-treated group, 21kHz ultrasound and microbubble contrast agent-treated group, 1MHz ultrasonic-treated group, the 1MHz ultrasound and microbubble contrast agent-treated group, and the microbubble contrast agent-treated group. The changes of histological damage, mitochondria damage, cell apoptosis, biochemical markers, and levels of PSA, iNOS, and SOD were determined.
Results: Significant tissue injury, mitochondria injury, and cell apoptosis were observed in 21kHz ultrasound and the microbubble contrast agent-treated group. Compared with the control and Sonovue-treated groups, the decreases in levels of PSA or increases in levels of iNOs and SOD in the other four groups were statistical significant (P< 0.05). The lowest levels of PSA and the highest levels of iNOs and SOD were observed in the 21kHz ultrasound and Sonovue-treated group, and compared with the other five groups, the changes in levels of PSA, iNOs, and SOD were statistically significant (P< 0.05). However, no significant changes in levels of AST, ALT, and BUN were observed between the six groups.
Conclusions: Our results suggest that lower frequency ultrasound may have better effect on benign prostatic hyperplasia and microbubble contrast agent application further strengthen this biological effect.
Written by:
Yang SL, Tang KQ, Bai WK, Zhao YW, Shen E, Tao JJ, Hu B. Are you the author?
Department of Ultrasound in Medicine, Shanghai Jiao Tong University Affiliated 6th People's Hospital, Shanghai Institute of Ultrasound in Medicine, Shanghai 200233, China, Shanghai, China.
Reference: J Endourol. 2013 Apr 22. Epub ahead of print.
doi: 10.1089/end.2012.0637
PubMed Abstract
PMID: 23607285
