Benign prostatic hyperplasia (BPH) is a common cause of male lower urinary tract symptoms (LUTS) that can reduce quality of life. Even if several drugs can be used in its treatment, the development of adverse drug reactions (ADRs) represents the most common cause of low adherence. In the present study, we evaluate both the efficacy and the safety of a new nutrient fixed combination of Pollen Extract plus Teupolioside, named Xipag®, in patients with LUTS. We conduct a pilot single center open label clinical study between 1 March 2020 and 30 June 2020 in patients with BPH referred to general practitioner's ambulatories. Male patients > 45 years, sexually active, with clinical symptoms of LUTS and with a diagnosis of HPB were enrolled and received one tablet/day of Xipag® (T0), for three months (T1: end of treatment). The IPSS and IIEF-5 questionnaires were carried out at T0 and T1 and represent the first end point, whereas the primary safety end point was considered the absence of ADR or of drug-drug interactions related to Xipag® administration. During the study period, 25 subjects aged 43 to 76 years (mean 62.7 ± 9) were enrolled and completed the study. The clinical evaluation in T1 documented that Xipag® induced a statistically significant improvement (p < 0.01) in symptoms, as documented by the IPSS questionnaire (range 22.7-88.9; mean 55.2 ± 23.6), without the development of ADRs. In conclusion, this is the first real-world study that showed the efficacy and the safety of Xipag® in the BPH patients with LUTS.
Life (Basel, Switzerland). 2022 Jun 27*** epublish ***
Lucia Muraca, Antonio Scuteri, Elisabetta Burdino, Gianmarco Marcianò, Vincenzo Rania, Luca Catarisano, Alessandro Casarella, Erika Cione, Caterina Palleria, Manuela Colosimo, Antonio Cutruzzolà, Cristina Vocca, Emanuele Basile, Rita Citraro, Gabriella Marsala, Giulio Di Mizio, Giovambattista De Sarro, Luca Gallelli
Department of Primary Care, ASP Catanzaro, 88100 Catanzaro, Italy., Department of Health Sciences, University "Magna Græcia" of Catanzaro, 88100 Catanzaro, Italy., Department of Pharmacy, Health and Nutritional Sciences, Department of Excellence 2018-2022, University of Calabria, Ed. Polifunzionale, Arcavacata di Rende, 87036 Rende, Italy., Operative Unit of Clinical Pharmacology, Mater Domini University Hospital, 88100 Catanzaro, Italy., Operative Unit of Microbiology and Virology, Pugliese Ciaccio Hospital, 88100 Catanzaro, Italy., Dipartimento del Farmaco, U.O.C. di Farmaceutica Convenzionata, 95100 Catania, Italy., Forensic Medicine, Department of Law, Economy and Sociology, University "Magna Græcia" of Catanzaro, 88100 Catanzaro, Italy.