A cross-sectional study was conducted to estimate the age-stratified normal levels and age-related changes in the risk predictors of benign prostatic hyperplasia (BPH) progression. A total of 4706 male participants aged 40 years or older in Zhengzhou (China) were enrolled. The values of the International Prostate Symptom Score (IPSS), prostate-specific antigen (PSA), prostate volume (PV), and postvoid residual urine volume (PVR) significantly increased with age. Nonlinear relationships between age and IPSS scores ≥8 (P for nonlinearity = 0.046), PSA level ≥1.6 ng ml-1, PV ≥31 ml, or PVR ≥39 ml (all P for nonlinearity <0.001) were observed. After the age of 61 years, the risk indicators related to BPH progression were positively correlated with age (odds ratio [OR] >1), regardless of the predictors of the IPSS score, PSA level, PV, or PVR; and the OR values increased gradually. Therefore, after the age of 61 years, the risk predictors related to BPH progression were positively correlated with age.
Asian journal of andrology. 2022 Apr 29 [Epub ahead of print]
Wei-Hao Shao, Cai-Fang Zheng, Yong-Chao Ge, Xiao-Rui Chen, Bo-Wen Zhang, Gai-Li Wang, Wei-Dong Zhang
Department of Epidemiology, School of Public Health, Zhengzhou University, Zhengzhou 450001, China., Department of Urology, The Third People's Hospital of Zhengzhou, Zhengzhou 450000, China.