Tamsulosin is the most potent adrenergic alpha-1 antagonist used for treatment of benign prostatic hyperplasia (BPH). Priapism has been reported as a rare side effect through direct inhibition of the sympathetic input necessary for detumesence.
We describe an otherwise healthy man with recurrent and then persistent unresolved priapism after the use of tamsulosin and concomitant use of ace inhibitor and beta blocker for hypertension. We then performed aspiration and intracavernosal irrigation of saline and vasoconstrictive agent.
Health-care professionals should inform all patients taking such medications about this rare but possible serious adverse effect. Tamsulosin is a useful medication for the management of Lower Urinary Tract Symptoms (LUTS) related to BPH and medical expulsion of distal ureteric calculi. However, its use may be associated on rare occasions with priapism, hence Health-care professionals should be aware in order to advice all patients taking such medications about this rare but serious adverse effect and to seek help as soon as possible.
With caution against the use of tamsulosin in hypertension treated patient, the possibility of the adverse effect can be more noticed and encourage practitioners to look for other alternatives that are safer and better for dealing with LUTS in the future and develop better treatment strategies.
International journal of surgery case reports. 2020 Jun 12 [Epub]
Johannes Cansius Prihadi, Christopher Kusumajaya
Department of Surgery, Division Urology, School of Medicine and Health Sciences, Atma Jaya Catholic University, Jl. Pluit Raya No. 2, Penjaringan, Utara, DKI Jakarta 14440, Indonesia. Electronic address: ., Department of Surgery, Division Urology, School of Medicine and Health Sciences, Atma Jaya Catholic University, Jl. Pluit Raya No. 2, Penjaringan, Utara, DKI Jakarta 14440, Indonesia. Electronic address: .