To investigate the changes of urinary NGF in patients with BPH after TURP, and the association between NGF and changes of OAB symptoms and long-term treatment outcome after surgery.
This was a prospective study of 178 patients with BPH from Peking University People's Hospital between January 2011 and January 2013. Urinary NGF levels (commercial ELISA kit), prostate volume (PV), International Prostate Symptom Score (IPSS), Quality of life (QoL), Overactive Bladder Symptom Score (OABSS), ultrasound estimated post-void residual (PVR), and urodynamics were assessed before surgery. Urinary NGF levels, IPSS, and OABSS were assessed again one year after TURP.
The urinary NGF/Cr levels were different between moderate and severe LUTS (10.513±4.255 vs. 12.334±4.048 pg/μmol, P=0.002). There was no significant difference between patients with III/IV and V/VI BOO grades (11.285±4.069 vs. 11.781±4.437 pg/μmol, P=0.354), but differences were significant for urinary NGF/Cr levels in patients with non-OAB, mild, moderate, and severe OAB (8.132±3.489, 10.128±3.817, 13.232±3.290, and 14.029±3.820 pg/μmol, P<0.001). One year after TURP, a decrease in urinary levels of NGF/Cr (8.978±4.022pg/μmol, P<0.001 vs. Baseline) and in IPSS and OABSS (10.2±5.4 and 4.3±3.7, respectively, P<0.001 vs. baseline) were observed. Compared with the Good outcome group, the Fair/Poor group had higher baseline NGF/Cr (12.319±4.017 vs. 11.015±4.298 pg/μmol, P=0.045), higher 1-year NGF/Cr (10.847±4.267 vs. 7.850±3.419 pg/μmol, P<0.001), and smaller NGF/Cr postsurgical change (1.472±4.928 vs. 3.165±4.863 pg/μmol, P=0.031).
NGF was associated with OAB symptoms in BPH patients, as well as with the assessment of successful long-term treatment outcome of BOO with symptoms of OAB.
The Journal of urology. 2018 Apr 06 [Epub ahead of print]
Hao Hu, Weiyu Zhang, Xianhui Liu, Huanrui Wang, Zhiwei Fang, Chen Liang, Tao Wang, Kexin Xu
Department of Urology, Peking University People's Hospital, No. 11 Xi Zhi Men South Street, Beijing, 100044, China., Department of Urology, the 1st Affiliated Hospital of Zhengzhou University, 1 Jianshe East Road, Zhengzhou 450052, China., Lymphatic Surgery, Beijing Shijitan Hospital, Capital Medical University, NO.10 Tieyi Roud, Yangfangdian Street, Haidian District, Beijing, 100038, China., Department of Urology, Peking University People's Hospital, No. 11 Xi Zhi Men South Street, Beijing, 100044, China. Electronic address: .