BACKGROUND AND OBJECTIVE: The aim is to evaluate tamsulosin efficacy and safety on the expulsion of distal ureteral stones compared to a standard therapy.
MATERIAL AND METHODS: Systematic searches were conducted on PubMed, SCOPUS and The Cochrane Library so as to identify randomized and controlled clinical trials in patients treated with tamsulosin with ureteral stone expulsion and adverse events published until 2014 December, without language restriction. Treatment effect was calculated along with the 95% confidence interval (95% CI), using the variance inverse method for random effects. Heterogeneity was determined by I2. Publication bias was assessed by Egger test.
RESULTS: The search identified 480 articles. Thirty-eight met the selection criteria, a total of 3,107 patients. The relative risk (RR) of expulsion was 1.53 (95% CI 1.38-1.69; I2=71%.), while the RR of adverse effects was 1.79 (95% CI 1.19-2,71; I2=0).
CONCLUSIONS: Tamsulosin treatment seems to bring on the expulsion of distal ureteral stones, although at the expense of an appreciable risk of side effects.
Written by:
Benítez Camps M, Cerain Herrero MJ, de Miguel Llorente N, Martorell Sole E, Flores Mateo G, Pedro Pijoan AM, Murillo-Huapaya C. Are you the author?
Centre d'Atenció Primària Gòtic, Barcelona, España; Centre d'Atenció Primària Can Vidalet, Esplugues de Llobregat, Barcelona, España; Centre d'Atenció Primària La Pau, Sant Martí, Barcelona, España; Unitat de Suport de la Recerca Tarragona, Institut Universitari d'Investigació en Atenció Primària (IDIAP) Jordi Gol, Tarragona, España; Centre d'Atenció Primària Sagrada Familia, Barcelona, España; 6Unidad Docente LLeida, Lleida, España.
Reference: Med Clin (Barc). 2015 May 14. pii: S0025-7753(15)00184-0.
doi: 10.1016/j.medcli.2015.01.029
PubMed Abstract
PMID: 25982524
Article in Spanish.