INTRODUCTION: The aim was to confirm that PSF (probability of stone formation) changed appropriately following medical therapy on recurrent stone formers.
MATERIALS AND METHODS: Data were collected on 26 Brazilian stone-formers. A baseline 24-hour urine collection was performed prior to treatment. Details of the medical treatment initiated for stone-disease were recorded. A PSF calculation was performed on the 24 hour urine sample using the 7 urinary parameters required: voided volume, oxalate, calcium, urate, pH, citrate and magnesium. A repeat 24-hour urine sample was performed for PSF calculation after treatment. Comparison was made between the PSF scores before and during treatment.
RESULTS: At baseline, 20 of the 26 patients (77%) had a high PSF score (> 0.5). Of the 26 patients, 17 (65%) showed an overall reduction in their PSF profiles with a medical treatment regimen. Eleven patients (42%) changed from a high risk (PSF > 0.5) to a low risk (PSF < 0.5) and 6 patients reduced their risk score but did not change risk category. Six (23%) patients remained in a high risk category (> 0.5) during both assessments.
CONCLUSIONS: The PSF score reduced following medical treatment in the majority of patients in this cohort.
Written by:
Turney B, Robertson W, Wiseman O, Amaro CR, Leitão VA, Silva IL, Amaro JL. Are you the author?
Department of Urology, University of Oxford, Oxford; United Kingdom; Deparment of Urolithiasis Research, Cambridge University Hospitals Trust, Cambridge, United Kingdom; Department of Urology, Cambridge University Hospitals Trust, Cambridge, United Kingdom; Department of Urinary, Lithiasis Metabolism Service, School of Medicine, São Paulo State University (UNESP), Botucatu, SP, Brazil; Department of Urology, School of Medicine, São Paulo State University (UNESP), Botucatu, SP, Brazil.
Reference: Int Braz J Urol. 2014 Jul-Aug;40(4):507-12.
doi: 10.1590/S1677-5538.IBJU.2014.04.09
PubMed Abstract
PMID: 25251955