Urinary composition is the result of the interplay of all metabolic processes, including all metabolites and toxins produced.
Any change in urine composition influences urinary supersaturation, the major thermodynamic driving force of crystal formation. Urolithiasis is a wide-spread disease with a prevalence rate of 4 % to 10 %. Formation risk of calcium-oxalate, by far the most common mineral in uroliths, is quantified by the Bonn-Risk-Index (BRI). The BRI measures induced crystal growth within native urine and shows superior diagnostic sensitivity and specificity compared to other urolithiasis risk indices. The concept of BRI quick test presented in this work allowes even untrained persons to easily determine the urolithiasis risk. Many diseases lack a simple, easily accessible and cost effective diagnostic approach to monitor their course and treatment success. Since BRI takes into account every constituent of native urine, it can be used to monitor a wide range of metabolic diseases.
Written by:
Laube N, Klein F, Bernsmann F, Fisang C. Are you the author?
Deutsches Harnsteinzentrum, Medizinisches Zentrum Bonn Friedensplatz; Fachbereich Medizintechnik und Technomathematik, Fachhochschule Aachen, Campus Jülich; NTTF Coatings GmbH, Rheinbreitbach; Klinik und Poliklinik für Urologie und Kinderurologie, Universitätsklinikum Bonn.
Reference: Dtsch Med Wochenschr. 2014 Aug;139(34-35):1721-5.
doi: 10.1055/s-0034-1370196
PubMed Abstract
PMID: 25116022
Article in German.
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