OBJECTIVE: To provide insight in causative factors of pediatric urolithiasis in The Netherlands, a non-endemic country.
PATIENTS AND METHODS: Data from 71 children with urolithiasis and stone analyses between 1996 and 2010 in the Radboud University Nijmegen Medical Centre were studied retrospectively. Patients (48 boys, 23 girls, ratio 2.1:1) were aged 0.5-18.3 years (mean 8.8, SD 5.6). All stone analyses were performed with FTIR spectroscopy.
RESULTS: Of the 49 patients with metabolic analysis, 78% showed one (n = 15) or more (n = 23) metabolic abnormalities. Forty-seven percent had hypercalciuria (n = 23), 31% had hyperoxaluria (n = 15), 29% hypocitraturia (n = 14), 10% hyperuricosuria (n = 5), 10% cystinuria (n = 5), and 6% had hypomagnesiuria (n = 3). Sixty-one percent of the stones were composed of calcium phosphate, calcium oxalate, or a combination of those. Twenty-six percent consisted of pure or mixed magnesium ammonium phosphate, 8.3% pure or mixed urate, and 8.3% cystine.
CONCLUSION: Children with urolithiasis in The Netherlands show stone composition similar to other Western European countries. However, a high percentage of metabolic abnormalities (78%) was found, indicating the need for extensive evaluation of pediatric urolithiasis to find underlying causes and thereby prevent stone recurrences. A close collaboration between a pediatric nephrologist and urologist is mandatory for optimal surgical and medical treatment.
Written by:
Rellum DM, Feitz WF, van Herwaarden AE, Schreuder MF. Are you the author?
Department of Pediatric Nephrology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
Reference: J Pediatr Urol. 2013 Aug 24. pii: S1477-5131(13)00206-4.
doi: 10.1016/j.jpurol.2013.07.019
PubMed Abstract
PMID: 23981680
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