Objective: To evaluate mepridine sparing effect of intravenous paracetamol in patients undergoing percutaneous nephrolithotomy (PCNL).
Materials and Methods: One hundred patients who underwent PCNL were randomized to paracetamol (n=50) and placebo (n=50) groups. Patients received 100cc of normal saline with or without 1gr intravenous paracetamol every 8 hours after PCNL up to 24 hours in the paracetamol and placebo groups, respectively. Patients in both groups received intramuscular mepridine in case of unrelieved pain. Visual analog scale (VAS) was used to evaluate pain intensity scores in the postoperative period. Total mepridine consumption, mean VAS score in the first 6 and 24 hours, demographic variables, operative variables, and side-effects were recorded.
Results: The mean VAS pain intensity scores at 6 and 24 hours were 50.22 and 41.32mm in the paracetamol, and 75.29 or 65.5 mm in the placebo group (P< 0.001).The mean consumed mepridine dose was 54.40 mg and 77.60 mg in paracetamol and placebo groups, respectively (P< 0.001).
Conclusion: In this study, intravenous paracetamol significantly reduced total mepridine consumption and pain intensity scores compared to placebo. Intravenous paracetamol can be an effective and safe part of multi-modal analgesia regimes for postoperative pain management after PCNL.
Written by:
Maghsoudi R -, Tabatabai M, Radfar MH, Movasaghi G, Etemadian M, Shati M, Amjadi M. Are you the author?
Hasheminejad Kidney Center (HKC), Endourology, Vanak Squ, Valiasr Ave, Valinejhad str, Tehran, Islamic Republic of Iran.
Reference: J Endourol. 2013 Aug 19. Epub ahead of print.
doi: 10.1089/end.2013.0267
PubMed Abstract
PMID: 23952097
UroToday.com Stone Disease Section
