Objective: To evaluate if the medical prophilaxis decreases the calcium-oxalate stone recurrences in children after percutaneous nephrolithotomy (PNL) or not.
To our knowledge this is the first study evaluate this topic in children after PNL.
Patients and Methods: We researched analysis of 42 children with calcium oxalate stone disease. They were divided into 2 groups. Twenty-two children had a followup with medical prophilaxis after PNL were included group I; 20 children did not have a medical prophilaxis were included group II. They were all stone-free and they were evaluated with 24-h urine analysis, blood samples; abdominal X-ray and ultrasonography. The avarage follow up was 25.9(12-42) mounts for group I, 24.6(14-40) mounths for group II.
Results: Age, gender, following times and 24-h urine samples were similar between groups (p>0,05). New stone formation was detected in 2(9.1%) and 7(35%) patients in group I and II, respectively. New stone formation is seem to be higher in group II, but because of the low number of patients, this difference was not statistically significant (p= 0.062). The number of recurrence was statistically higher in group II (p=0.032). SFR was calculated as 0.034 and 0.2 per patient per year for group I and II, respectively. This difference for SFR between groups was statistically significant (p=0.028).
Conclusion: Medical prophilaxis of children after PNL can reduce the number of new stone formation and SFR. Although it was not statistically significant because of low patient numbers, recurrence rate was detected higher in patients who did not have medical prophilaxis.
Written by:
Oguz U, Unsal A. Are you the author?
Kecioren Training and Research Hospital, Urology, Ankara, Turkey.
Reference: J Endourol. 2012 Aug 14. Epub ahead of print.
doi: 10.1089/end.2012.0243
PubMed Abstract
PMID: 22891769
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